Event Title
Mild traumatic brain injury in male and female rats: Characterization of a new injury paradigm
Location
Parker-Reed, SSWAC
Start Date
30-4-2015 11:00 AM
End Date
30-4-2015 1:55 PM
Project Type
Poster
Description
According to the Centers for Disease Control and Prevention, traumatic brain injuries (TBI) contribute to approximately one third of all injury-related deaths in the United States. Of these injuries, approximately 75% are concussion or other forms of mild TBI and evidence is mounting that even these mild forms may have significant adverse effects on cognition and emotional functioning. Many models in both mice and rats have been previously proposed, however these models apply force through either projectiles or blasts to a stationary animal, which do not include the acceleration of the animals head, as seen in common human sports-related injury mechanisms. In addition, a rotational component of the head directly after impact, which is considered to be a key component to the persistent negative effects that follow, is not included in these models. This study sets out to create a novel concussion rat model, which allows for the most accurate simulation of the human concussion injury mechanism. Furthermore, this study will explore the implications of sex differences on the concussion injury symptom and recovery pathology. This research has the potential to open the door to a new way to study concussion and expand our understanding of the injury. It will also complement and add to work already ongoing at Colby on sports-related concussion in humans.
Sponsoring Department
Colby College. Psychology Dept.
CLAS Field of Study
Social Sciences
Event Website
http://www.colby.edu/clas
ID
1594
Mild traumatic brain injury in male and female rats: Characterization of a new injury paradigm
Parker-Reed, SSWAC
According to the Centers for Disease Control and Prevention, traumatic brain injuries (TBI) contribute to approximately one third of all injury-related deaths in the United States. Of these injuries, approximately 75% are concussion or other forms of mild TBI and evidence is mounting that even these mild forms may have significant adverse effects on cognition and emotional functioning. Many models in both mice and rats have been previously proposed, however these models apply force through either projectiles or blasts to a stationary animal, which do not include the acceleration of the animals head, as seen in common human sports-related injury mechanisms. In addition, a rotational component of the head directly after impact, which is considered to be a key component to the persistent negative effects that follow, is not included in these models. This study sets out to create a novel concussion rat model, which allows for the most accurate simulation of the human concussion injury mechanism. Furthermore, this study will explore the implications of sex differences on the concussion injury symptom and recovery pathology. This research has the potential to open the door to a new way to study concussion and expand our understanding of the injury. It will also complement and add to work already ongoing at Colby on sports-related concussion in humans.
https://digitalcommons.colby.edu/clas/2015/program/55