Date of Award

1968

Document Type

Senior Scholars Paper (Open Access)

Department

Colby College. Biology Dept.

Advisor(s)

(unknown)

Abstract

Briefly. the rennin-angiotensin-aldosterone triangle can be thou ht of as a regulator of renal perfusion. Renin, released by the kidney in response to any threat in its perfusion n, acts on its substrate to produce angiotensin I, a mild vasoconstrictor which by means of plasma converting enzymes secretes angiotensint II. This latter product not only stimulates aldosterone output by the adrenals, but also supports the animals’ blood pressure. With aldosterone binding at the distal tubules in the kidney and this causing increased sodium retention, restoration of renal perfusion occurs – a phenomenon which shuts off the original signal for rennin secretion. To more fully understand the relationship between blood pressure and rennin granularity in mice, physiograph readings and juxtaglomerular indices from members of the A/J and SWR strains along with their offspring from reciprocal crosses were compared. A number of results were obtained: 1. Blood.pressure as a generally negative correlation with weighted indices: wei~hted i d ces: 2. a. SWR mean blood pressure values are higher than A/J values; b. F1 and F2 have values somewhere in between indicating the inheritability of blood pressure; 3. a. Body weights of males is greater than females just as the kidney weights are heavier. b. There is a positive relationship between body and kidney weight; 4. a. Indices of males of a strain are less than those of the females of the same strain primarily because the values of dense glomeruli for females is on the whole greater. b. Values of F1 an F2 of the juxtaglomerular index do not necessarily lie within parental levels; 5. Hematocrit values of 1l and F2 are between parental values.

Keywords

Blood pressure, rennin granularity, rennin-angiotensin-aldosterone, mouse kidney, physiograph readings, juxtaglomerular indices

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