Computational study of the reactivity differences of two carbonyl dianions

Sylvia Haller, Colby College

Document Type Honors Thesis (Open Access)


Experimentally an unexpected reactivity difference was observed between a diester and imide system. Both A and C were thought to react similarly. However, while the diester, A, underwent a dienolate-mediated oxidation to form the corresponding alkene product, the imide, C, was unreactive. [see full thesis for illustrations] This study examines this reactivity difference between the diester and the imide systems through a computational approach. The differences between the two systems will be considered at each step of the proposed mechanism. Also considered in this study is the appropriate method for handling dianions computationally.