Event Title

The Neruoprotective Effects of Postnatal Choline Supplementation on a Rat Model of Fetal Alcohol Syndrome

Presenter Information

Julia Mitchell, Colby CollegeFollow

Location

Parker-Reed, SSWAC

Start Date

1-5-2014 2:00 PM

End Date

1-5-2014 3:00 PM

Project Type

Poster

Description

In this study, the effects of prenatal ethanol exposure and postnatal choline supplementation on hippocampal neurogenesis in the rat brain were explored. The brains of rats that were prenatally exposed to ethanol and the brains of rats that were prenatally given a matched kilocal diet were compared to identify the effects of ethanol on hippocampal neurogenesis at postnatal day (PD) 24. The brains of rats that were prenatally exposed to ethanol and given a choline supplemented or regular diet, and rats that were prenatally given a control diet and postnatally given either a choline supplemented or regular diet were also compared to identify the effect of ethanol on the rates of neurogenesis and cholines effect on prenatal ethanol exposure, at PD 50. Ethanol treated rats sacrificed at PD 24 showed significantly less hippocampal neurogenesis than control diet rats. The effect of ethanol on the rate of neurogenesis seemed to remain constant over time, when brains sacrificed at PD 24 and PD 50 were compared. Choline showed an attenuating effect on hippocampal neurogenesis for prenatal exposure to ethanol, and also showed a boost in neurogenesis for control-fed animals. Overall, choline was shown to attenuate for the effects of prenatal ethanol exposure, indicating that choline supplementation may be a possible cure for Fetal Alcohol Syndrome.

Sponsoring Department

Colby College. Psychology Dept.

CLAS Field of Study

Social Sciences

Event Website

http://www.colby.edu/clas

ID

247

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May 1st, 2:00 PM May 1st, 3:00 PM

The Neruoprotective Effects of Postnatal Choline Supplementation on a Rat Model of Fetal Alcohol Syndrome

Parker-Reed, SSWAC

In this study, the effects of prenatal ethanol exposure and postnatal choline supplementation on hippocampal neurogenesis in the rat brain were explored. The brains of rats that were prenatally exposed to ethanol and the brains of rats that were prenatally given a matched kilocal diet were compared to identify the effects of ethanol on hippocampal neurogenesis at postnatal day (PD) 24. The brains of rats that were prenatally exposed to ethanol and given a choline supplemented or regular diet, and rats that were prenatally given a control diet and postnatally given either a choline supplemented or regular diet were also compared to identify the effect of ethanol on the rates of neurogenesis and cholines effect on prenatal ethanol exposure, at PD 50. Ethanol treated rats sacrificed at PD 24 showed significantly less hippocampal neurogenesis than control diet rats. The effect of ethanol on the rate of neurogenesis seemed to remain constant over time, when brains sacrificed at PD 24 and PD 50 were compared. Choline showed an attenuating effect on hippocampal neurogenesis for prenatal exposure to ethanol, and also showed a boost in neurogenesis for control-fed animals. Overall, choline was shown to attenuate for the effects of prenatal ethanol exposure, indicating that choline supplementation may be a possible cure for Fetal Alcohol Syndrome.

http://digitalcommons.colby.edu/clas/2014/program/210