Date of Award


Document Type

Senior Scholars Paper (Colby Access Only)


Colby College. Chemistry Dept.


George Maier

Second Advisor

William B. Miller


Hypertension of renal origin has been thought to exist for some time, but it was not until 1934 that it became subject to active investigation. Many attempts, mostly unsuccessful, to elicit hypertension by various manipulations of the kidneys, led to the successful attempt by Goldblatt. Etiologically, association of pulse and changes of circulation of the blood with kidney disease dates back to about 200 B.C. A Chinese physician, Choun-You-J stated "When the pulse, upon depressing, is very firm and upon superficial palpitation tight, then the disease has its sear in the kidney. Throughout history, statements such as this arise, but with no great concern by the medical profession. In 1827 the belief or theory that a relationship exists between cardiac and renal disease was revived by an English physician named Richard Bright. This implied to later physicians that hypertension was frequently involved in kidney disease.


hypertension, renal, kidney disease, heavy metals, bovine renin


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