Event Title

The Effects of Acute Ethanol Exposure on the Innate Immune System of Zebrafish

Presenter Information

Paul Macklis, Colby CollegeFollow

Location

Diamond 141

Start Date

30-4-2015 1:20 PM

End Date

30-4-2015 2:25 PM

Project Type

Presentation- Restricted to Campus Access

Description

Previous research has shown that ethanol consumption results in a decrease in innate immune activity in mice. In this study, I examine the effects of acute ethanol exposure on the innate immune activity in zebrafish, an effective model organism for immunological study. Zebrafish were exposed to a 1% ethanol solution for one hour and then sacrificed. Their innate immune cells were harvested and exposed to fluorescently labelled pHrodo E. coli to track the phagocytic activity of the innate cells via FACS. It appears that acute ethanol exposure is actually promoting phagocytic activity in zebrafish.

Faculty Sponsor

Judy Stone

Sponsoring Department

Colby College. Biology Dept.

CLAS Field of Study

Natural Sciences

Event Website

http://www.colby.edu/clas

ID

1135

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Apr 30th, 1:20 PM Apr 30th, 2:25 PM

The Effects of Acute Ethanol Exposure on the Innate Immune System of Zebrafish

Diamond 141

Previous research has shown that ethanol consumption results in a decrease in innate immune activity in mice. In this study, I examine the effects of acute ethanol exposure on the innate immune activity in zebrafish, an effective model organism for immunological study. Zebrafish were exposed to a 1% ethanol solution for one hour and then sacrificed. Their innate immune cells were harvested and exposed to fluorescently labelled pHrodo E. coli to track the phagocytic activity of the innate cells via FACS. It appears that acute ethanol exposure is actually promoting phagocytic activity in zebrafish.

http://digitalcommons.colby.edu/clas/2015/program/420