Event Title

The Assessment and Comparison of Behavior in a Disrupted-In-Schizophrenia-1 Knockout Model of Schizophrenia Combined with the Administration of MK-801

Location

Diamond 242

Start Date

30-4-2015 3:15 PM

End Date

30-4-2015 3:55 PM

Project Type

Presentation

Description

Schizophrenia is a debilitating disease affecting 3.5 million Americans without any directly associated cause or course of highly effective treatment. Therefore, researchers are consistently searching for new and more effective ways to study and treat the disorder. Animal models have been instrumental in this area of research for treatments. Despite this, a model encompassing the majority of symptoms has yet to be developed. A new and promising genetic model involving the deletion of the Disrupted-In-Schizophrenia 1 gene (DISC 1), a gene strongly linked to the development of mental illness in a European family, has been recently developed in rats. The goal of this study was to assess the viability of this model and to study the characteristics and potential behavioral overlap it might share with the pharmacological model utilizing MK-801. To assess this, a number of measures involving the assessment of pre-pulse inhibition (PPI), a indicator of sensorimotor gating ability, the Morris Water Maze, a measure of spatial memory, and the object recognition paradigm, used for the assessment of novel memory were used. Results revealed that there was a clear effect of the genetic model on the ability for rats to curb their startle response during PPI assessment . . .

Faculty Sponsor

Melissa Glenn

Sponsoring Department

Colby College. Psychology Dept.

CLAS Field of Study

Social Sciences

Event Website

http://www.colby.edu/clas

ID

1233

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Apr 30th, 3:15 PM Apr 30th, 3:55 PM

The Assessment and Comparison of Behavior in a Disrupted-In-Schizophrenia-1 Knockout Model of Schizophrenia Combined with the Administration of MK-801

Diamond 242

Schizophrenia is a debilitating disease affecting 3.5 million Americans without any directly associated cause or course of highly effective treatment. Therefore, researchers are consistently searching for new and more effective ways to study and treat the disorder. Animal models have been instrumental in this area of research for treatments. Despite this, a model encompassing the majority of symptoms has yet to be developed. A new and promising genetic model involving the deletion of the Disrupted-In-Schizophrenia 1 gene (DISC 1), a gene strongly linked to the development of mental illness in a European family, has been recently developed in rats. The goal of this study was to assess the viability of this model and to study the characteristics and potential behavioral overlap it might share with the pharmacological model utilizing MK-801. To assess this, a number of measures involving the assessment of pre-pulse inhibition (PPI), a indicator of sensorimotor gating ability, the Morris Water Maze, a measure of spatial memory, and the object recognition paradigm, used for the assessment of novel memory were used. Results revealed that there was a clear effect of the genetic model on the ability for rats to curb their startle response during PPI assessment . . .

http://digitalcommons.colby.edu/clas/2015/program/359